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2024 ICD-10-CM Diagnosis Code R53.1: Weakness - SPRY

R53.1 is a billable/specific code within the International Classification of Diseases, 10th Revision, Clinical Modification (ICD-10-CM) system. It signifies the diagnosis of weakness, a general term for diminished or absent energy and strength. This code is used for reimbursement in healthcare claims submitted on or after October 1, 2015.

Understanding the Code Structure
  • 2016-2024: These years indicate the code's effective date range. R53.1 became a valid code in 2016 and will remain active in 2024.
  • Billable/Specific Code: This denotes the code can be used for billing purposes, unlike some non-billable codes used for internal documentation.
Exclusions and Related Codes

Several diagnoses are explicitly excluded from being coded alongside R53.1:

  • Age-related weakness (R54)
  • Muscle weakness (generalized) (M62.81)
  • Sarcopenia (M62.84)
  • Senile asthenia (R54)

This implies that if the weakness stems from any of these specific conditions, R53.1 should not be used. Additionally, particular codes (listed under Diagnosis Index entries) have back-references to R53.1, indicating a potential relationship between them.

Clinical Understanding of Weakness

R53.1 signifies a symptom characterized by:

  • Diminished or absent energy and strength
  • Debility or lack of stamina
  • Physical weakness, impacting movement and performance
  • Potential mental fatigue or lack of concentration

This broad definition encompasses various forms of weakness, highlighting its role as a general symptom rather than a specific diagnosis.

Grouping and Reimbursement:

R53.1 falls under specific Diagnostic Related Groups (DRGs), namely 947 Signs and symptoms with MCC and 948 Signs and symptoms without MCC. These DRGs group diagnoses with similar resource utilization to estimate reimbursement payments for hospital stays.

Historical Context and Conversion:

R53.1 entered the ICD-10-CM coding system in 2016 and has remained unaltered since then, indicating its consistent relevance in capturing the symptoms of weakness. Notably, there is no direct equivalent for R53.1 in the older ICD-9-CM coding system.


R53.1 can be used in various contexts, such as:

  • Documenting symptoms: When weakness is a primary complaint or secondary symptom of another condition.
  • Diagnosing fatigue-related disorders: As a symptom of chronic fatigue syndrome or post-viral fatigue.
  • Tracking treatment progress: Monitoring changes in strength and energy levels during treatment.

R53.1 plays a crucial role in healthcare documentation and reimbursement by providing a standardized code for the symptoms of weakness. Understanding its application and limitations ensures accurate coding and facilitates effective communication within the healthcare system.

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