Mounjaro & Blue Cross Blue Shield: What to Know About Step Therapy and Prior Authorization

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SPRY
May 13, 2025
5 min read
 prior authorization for mounjaro blue cross blue shield

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Do you find it challenging to get treatment approvals for your patients with the constant delays? Insurers often require physicians and physical therapists to handle complex guidelines before authorizing prescriptions or treatments. These processes aim to balance clinical efficacy, patient safety, and cost, but they can add significant stress and delays to patient care.  

Patient care may be hampered by approval delays, necessitating more paperwork, appeals, or direct correspondence with the insurer. A survey by the 2024 American Medical Association (AMA) revealed that 24% of physicians reported that PA has led to serious adverse events for patients, including hospitalization, permanent impairment, or death.  Step therapy, prior authorization for Mounjaro, Blue Cross Blue Shield, and prior authorization programs ensure proper medication use and reduce healthcare costs. 

In this blog, we'll discuss how PA and step therapy can streamline approvals, avoid common pitfalls, and ultimately improve the care you provide to your patients.

What is Prior Authorization?

Before prescribing specific drugs, therapies, or procedures, healthcare providers must obtain insurer approval under the prior authorization (PA) policy. Insurers use this process to control costs, prevent unnecessary medical procedures, and ensure adherence to clinical guidelines.

What are the Objectives of Prior Authorization?

Insurers require prior authorization for certain medications, imaging tests, and medical procedures. They mandate clinical justifications from physicians and physical therapists before granting coverage. This process ensures:

  • Patients receive appropriate and effective care.
  • Healthcare costs remain controlled by reducing the use of expensive or unnecessary treatments.
  • Providers adhere to evidence-based treatment guidelines.

If prior authorization is not obtained, prescribed treatments may not be covered by insurance, leading to delays or out-of-pocket costs.

Why Some Medications Require Prior Authorization?

Insurers enforce PA requirements for certain drugs due to:

  • High costs necessitate cost-containment measures.
  • Safety concerns that require further evaluation before use.
  • Availability of lower-cost alternatives that are equally effective.
  • There is a need for a stepwise treatment approach when multiple therapy options exist.

Additionally, insurers may require prior authorization for advanced rehabilitation techniques, specialized equipment, or therapy sessions exceeding standard coverage limits.

What is Mounjaro Blue Cross Blue Shield with PA and Step Therapy?

Blue Cross Blue Shield (BCBS) has rules called prior authorization (PA) and step therapy (ST) to help manage medications like Mounjaro (tirzepatide) and make sure treatment is safe, effective, and affordable.

Mounjaro and BCBS Step Therapy

For some BCBS plans, such as those in Massachusetts, Mounjaro is part of Step 2 in the treatment for type 2 diabetes. This means that before Mounjaro can be approved, patients need to have already tried two Step 1 medications, like Ozempic or Trulicity, and shown that those didn’t work well enough or caused problems. This process encourages using cheaper treatments before moving on to more expensive ones.

Prior Authorization Requirements

BCBS usually requires prior authorization for Mounjaro, which means doctors have to provide certain documents, including:

  • Proof of a type 2 diabetes diagnosis.

  • Records of trying Step 1 medications, including how much was taken, for how long, and why they were stopped, if applicable.

  • Medical reasons why Mounjaro is needed instead of other options.

If these documents aren’t provided, or if the patient hasn’t tried the required treatments, the approval may be denied.

Patients and healthcare providers should carefully check the specific rules of their BCBS plan since they can be different depending on the region or plan. It’s a good idea to contact BCBS directly or look at the plan’s formulary (list of approved medications) to understand what documentation is needed. Being well-prepared can help make the approval process easier and faster.

How Does Step Therapy and PA Affect Patients and Providers?

Step therapy and prior authorization (PA) programs impact patient care, administrative procedures, and treatment decisions. While these processes aim to ensure appropriate treatments and control costs, they often create challenges for both patients and providers.

1. Delays in Patient Treatment

Step therapy and PA can delay necessary treatments, causing patients to wait for insurance approvals or face interrupted care. This can lead to worsened symptoms or delayed rehabilitation, affecting recovery timelines.

2. Increased Administrative Burden on Providers

Physicians and PTs face complex paperwork and frequent insurer follow-ups to obtain PA approvals, increasing workload and diverting attention from direct patient care. While ePA systems help, insurer inconsistencies continue to add strain.

3. Higher Treatment Costs for Patients

Denied PA requests or step therapy can result in higher out-of-pocket costs for patients, including paying for uninsured treatments or medications. Delays may force patients to switch to less effective alternatives or discontinue treatments or therapy.

4 .Provider Burnout and Dissatisfaction

Repeated denials and rigid step therapy policies contribute to provider burnout, with more time spent on appeals than patient care, reducing job satisfaction and healthcare efficiency.

5. Risk of Poor Health Outcomes

PA restrictions may drive treatment decisions based on insurer policies rather than clinical judgment, leading to delayed interventions and increased risk of complications, hospitalizations, or patient non-compliance.

Streamlining PA processes and improving insurer-provider collaboration can help mitigate these negative effects, ensuring better patient outcomes.

How Do Step Therapy Programs Work in Prior Authorization?

Before approving costlier treatments, insurance companies use step therapy to ensure patients receive clinically appropriate and cost-effective options. Under this program, physicians and physical therapists must first prescribe less expensive, first-line treatments before requesting PA for advanced therapies.

1. How Step Therapy Works?

Step therapy follows a structured approach:

  • Patients start with insurer-recommended treatments, typically generic or lower-cost options.
  • If Step 1 treatments fail, cause adverse side effects, or are ineffective, insurers may approve the next stage of therapy.
  • Patients who demonstrate medical necessity may gain access to more specialized or expensive treatments (Step 3).

To ensure smooth progression, physicians and therapists must document each treatment step.

2. Why Insurance Companies Require Step Therapy?

Insurers implement step therapy to lower healthcare costs by prioritizing affordable treatments. It ensures patients try first-line therapies before advancing to costlier or newer alternatives, and lessens risks associated with high-risk medications or treatments. While step therapy may delay access to optimal treatments, it aligns with evidence-based guidelines. To minimize disruptions, providers must handle these protocols.

3. How to Manage Step Therapy with Prior Authorization?

To ensure approval, providers should:

  • Verify the insurer’s step therapy requirements before prescribing.
  • Maintain detailed records of treatment history, including failed medications or therapies.
  • Submit an exception request when step therapy causes adverse effects or delays patient care.

A well-documented PA request can help expedite approvals, ensuring patients receive necessary treatments without unnecessary delays.

What are the Common Reasons for Prior Authorization Denials?

Insurers reject PA requests for various reasons, often delaying patient care. Physicians and physical therapists must understand these issues to prevent rejections and expedite approvals.

1. Incorrect or Incomplete Documentation

To approve PA requests, insurers require specific clinical information. Common documentation errors include missing treatment history or diagnosis codes, the request lacking complete medical records, and incorrect patient or provider details. To prevent unnecessary delays, providers, and PTs should thoroughly review all documents before submission.

2. Not Fulfilling Step Therapy Requirements

Insurers may deny PA requests if patients fail to complete required step therapy protocols. Common reasons include skipping lower-cost or insurer-recommended treatments, lack of evidence proving first-line treatments are ineffective, and insufficient medical rationale for bypassing step therapy. Submitting a clear treatment history and a justification for any exceptions can reduce denial risks.

3. Non-formulary or Restricted Medications

PA requests are often denied when prescribed drugs are not on the insurer’s formulary. Denials occur when the prescribed drug has a cheaper, covered alternative. The insurer classifies the medication as experimental or off-label, and when the provider fails to request an exception for non-formulary drugs. Consulting the insurer’s formulary before prescribing helps prevent coverage issues.

4. Lack of Medical Necessity Justification

If medical necessity is unclear, insurers reject PA requests. Common reasons include clinical notes lacking sufficient supporting evidence, alternative treatments match with the insurer’s policies, and absence of recent test results or objective findings. Providers, and PTs should clearly explain why the requested treatment is necessary and why alternatives are unsuitable.

5. Expired or Incorrect PA Requests

Administrative errors often lead to denials, such as, PA approvals expire before treatment begins. Requests include outdated codes or violate insurance policies, and submissions are sent to the wrong department. Avoid rejections by verifying submission channels, coding accuracy, and PA validity before sending requests.

6. Coverage Limitations or Policy Exclusions

If a requested treatment falls outside coverage parameters, insurers deny PA requests. Common reasons include annual limits on visits or treatment sessions, plan-specific exclusions for certain medications or procedures, and out-of-network provider restrictions. Before submitting PA requests, providers should confirm coverage details with the insurer.

By addressing these common issues, physicians and physical therapists can reduce denial rates, expedite approvals, and ensure patients receive essential care without interruptions.

What is the PA Denial and Appeal Process?

Insurers may deny PA requests for various reasons, but providers have the right to contest these decisions through a formal appeals process. This process helps physicians and physical therapists secure the treatments their patients need.

1. The Provider’s Role in Filing an Appeal

Physicians and physical therapists who receive a PA denial must act promptly. The appeals process typically includes the following steps:

  • Reviewing the denial letter: Identify the reason for rejection and check for any missing supporting documentation.
  • Gathering supporting documentation: Submit clinical notes, medical necessity documentation, treatment history, and diagnostic findings.
  • Filing a formal appeal: Follow the insurer’s procedures, which may include phone reviews, online submissions, or written requests.
  • Requesting a peer-to-peer review: Engage in a direct discussion with the insurer’s medical director to justify the requested treatment.

Timely submissions and thorough documentation increase the likelihood of overturning a denial.

2. Typical Appeal Outcomes

The results of appeals vary based on the insurer’s review process. Common outcomes include, the insurer authorizes the treatment after receiving additional medical justification. The insurer approves a revised version of the request, such as a different treatment duration or a lower dosage. The insurance company maintains the denial, requiring further escalation or alternative treatment options.

If an insurer denies coverage after multiple appeals, patients and providers may request an independent medical review. Knowing these options helps healthcare professionals prepare for the next steps in patient care.

3. Appeals Success Rate and Approval Prospects After Review

The success rate of PA appeals depends on the treatment type, insurer policies, and medical justification. Research shows that approximately 50% of denied PA requests are overturned on the first appeal when providers present strong clinical evidence. 

Peer-to-peer reviews often result in higher approval rates by allowing direct provider-insurer discussions. External reviews can lead to approval rates exceeding 60%, particularly for high-cost treatments with clear medical necessity.

Physicians and PTs should continue to challenge unjustified denials. Clear documentation, insurer communication, and knowledge of state appeal rights improve approval chances.

Spry reduces 35% of PA denials by streamlining the submission of clinical diagnosis codes and treatment histories. Through the integration of electronic prior authorization (ePA), Spry ensures accurate documentation and expedited processing. As a result, step therapy requirements are better met, approval rates increase, and patients can receive necessary treatments more quickly.

Importance of Drug Information in Prior Authorization

Before approving prior authorization (PA) requests, insurers require comprehensive drug information. To demonstrate medical necessity and prevent denials, physicians and physical therapists must provide precise details about medication selection, dosage, and therapeutic benefits.

1. Classification of Drugs and Their Formulary Status

Insurers have formularies that categorize drugs by cost, availability, and preference. Providers must check the prescribed medication’s tier and verify whether generic alternatives are preferred. Confirm any coverage restrictions, such as quantity limits or step therapy. Non-formulary medications without justification may lead to PA denials or alternative treatment suggestions.

2. Justification for Dosage, Frequency, and Duration

Insurers need precise dosage details to assess medical necessity. Providers must document FDA-approved indications, standard dosing guidelines consistent with clinical best practices, and adjustments based on patient factors like age or weight. Clear dosage justification speeds up PA approvals.

3. Providing Clinical Support and Therapeutic Rationale

Insurers assess prior treatment outcomes and medical literature to confirm the necessity of prescribed medications. Providers should submit clinical guidelines, peer-reviewed studies, and treatment history to support medication choices. Strong clinical evidence increases the chances of PA approval.

When providers present strong clinical evidence, insurers are more likely to approve PA requests.

How to Obtain Prior Authorization?

To obtain PA for drugs, treatments, or procedures, physicians and physical therapists must adhere to insurer-specific regulations. A systematic approach improves patient care and reduces approval delays.

1 .Examine the Insurance Requirements

Insurers provide PA guidelines outlining covered treatments, required documentation, and submission procedures. Providers should:

  • Check the most recent PA criteria on the insurer’s web portal.
  • Verify alternative therapies and formulary limitations.
  • Confirm patient-specific coverage, including copays and deductibles.

2. Assemble the Required Documentation

Before granting PA requests, insurers require clinical justifications. Providers and PTs should prepare medical history and diagnosis codes proving the need for treatment, results of prior treatments, including unsuccessful alternatives. They should also prepare Imaging reports, laboratory tests, or therapy progress notes.

3. Submit the PA Request

Providers can submit requests through:

  • Electronic Prior Authorization (ePA): Integrated EHR systems allow faster processing.
  • Online portals or fax: Common submission methods.
  • Phone authorization: Used for urgent cases; providers can speak directly with the insurer.

4 .Respond to and Follow Up on Additional Requests

Insurers may request more documentation or clarification. Providers and PTs should monitor submission status through insurer portals or designated contacts. They should respond promptly to requests for additional information. Contact insurer case managers for expedited approvals in urgent cases.

5. Appeal Denied Requests When Necessary

Insurers may deny PA due to incomplete documentation, the need for alternative treatments, or financial concerns. Providers can:

  • Submit a reconsideration request with additional medical evidence.
  • File a formal appeal following the insurer’s procedures.
  • Discuss medical necessity with the insurer’s medical director through peer-to-peer reviews.

A proactive approach ensures compliance, reduces delays and improves patient access to essential treatments.

By guaranteeing correct documentation of every treatment phase, cutting down on delays, and ensuring adherence to insurance regulations, Spry improves step therapy management. Providers can expedite the filing of step therapy exception requests by utilizing their ePA tools, which can help resolve issues such as unfavorable side effects or ineffective first-line treatments.

Conclusion

Step therapy, prior authorization for Mounjaro Blue Cross Blue Shield, and prior authorization (PA) programs impact patient care, administrative workflows, and treatment decisions. While these processes help insurers control costs and ensure the appropriate use of medications, they often cause delays and increase the workload for providers.

To prevent rejections and secure timely approvals, physicians and physical therapists must submit thorough and accurate documentation. This includes evidence of medical necessity, medication histories, diagnosis codes, and treatment adherence records. If denials occur, providers should file appeals promptly, supporting their claims with peer-reviewed clinical data and insurer-specific requirements.

With automated tracking, Spry helps physical therapists handle Mounjaro PA and step therapy while reducing prior authorization workloads by 40%. Its system, which integrates with the EMR, increases approval rates by 30%, ensuring timely and accurate submissions. By optimizing workflows, Spry minimizes delays and improves patient access to treatments. Schedule a demo with Spry today.

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